Stavros Stavropoulos, MD, performs an Endoscopic full-thickness resection for appendiceal orifice polyp using OVESCO full thickness resection device. The patient is a 71-year-old woman with a history of hypertension, diabetes, and hyperlipidemia. Patient is presenting for removal of an appendiceal orifice polyp. Patient was found to have a 10mm intra-appendiceal orifice polyp during surveillance colonoscopy for personal history of colonic polyps. This video is part of the 11th Annual Long Island Live Endoscopy Course, Frontiers of Endoscopic Surgery.